Collection: Senolytics

Senescent cells are cells that have stopped dividing but refuse to die. In small numbers they serve useful purposes, helping wounds heal and suppressing tumors. As they accumulate with age, however, they secrete a cocktail of inflammatory signals, known as the senescence-associated secretory phenotype or SASP, that disrupts the healthy tissue around them. Researchers sometimes call them zombie cells. Senolytics are compounds studied for selectively clearing these cells, and the Welzo Ultra Purity Senolytics collection offers the two flavonoids with the strongest research at verified 98% purity.

Senolytics versus senomorphics

The field uses two terms. Senolytics are compounds studied for inducing senescent cells to self-destruct, which is why they are often taken intermittently rather than daily. Senomorphics are compounds studied for suppressing the harmful SASP signals without necessarily clearing the cells. Fisetin is the most researched natural senolytic; luteolin is studied in both categories; and apigenin is primarily studied as a senomorphic. Together they cover both strategies. This is one of the newest areas in longevity science, and it sits alongside autophagy and NAD+ as the main mechanisms addressed in Longevity & Healthy Aging.

Senolytic ingredients in this collection

• Fisetin Pro 500mg (98% purity): a flavonoid found in strawberries and apples, identified in screening studies as one of the most potent natural senolytics. Human trials have typically used high doses for two consecutive days each month, which a 500mg capsule makes practical.
• Neuronot Luteolin 500mg (98% purity): a flavonoid found in celery, parsley and chamomile, studied as a senolytic and for its interaction with microglia, the brain's immune cells. It also appears in Brain Health & Cognitive Support.
• Apigenin: the chamomile flavonoid studied as a senomorphic that suppresses SASP signaling, and separately valued for sleep. See Sleep & Recovery.

Why purity matters here

Flavonoids are poorly absorbed and quickly metabolized, so the dose that reaches tissue depends heavily on the purity of what you swallow. A 500mg capsule of 98% fisetin delivers 490mg of the active compound; a 500mg capsule of a 10% extract delivers 50mg. Welzo states purity on the label for exactly this reason. Taking fisetin with a meal containing fat can improve absorption, and some customers pair it with piperine or quercetin-containing foods.

How senolytics fit into a longevity routine

Most customers run senolytics as a periodic layer on top of a daily foundation of NAD+ support and mitochondrial nutrients. A common pattern is daily NMN, resveratrol and TMG from NAD+ Boosters, with fisetin taken in a concentrated pulse once a month. Luteolin and apigenin are generally taken daily. Spermidine and urolithin A, which address cellular recycling rather than senescent-cell clearance, are the complementary mechanisms covered in Autophagy Support.

Why Welzo Ultra Purity

Welzo is a UK-founded health company trusted by more than 200,000 customers and backed by over 27,000 five-star reviews across the Welzo platform. Every senolytic in this collection is manufactured to GMP standards, independently third-party tested for purity and potency, and supplied in vegan capsules with no fillers, binders or artificial colors. Batch certificates of analysis are available so the 98% on the label can be verified.

Frequently asked questions

What is the best senolytic supplement?

Fisetin has the most research as a natural senolytic and is the compound used in the leading human trials. Luteolin is the most studied alternative, and the two are often taken together.

Should senolytics be taken every day?

Fisetin is usually taken intermittently, for example two consecutive days per month, mirroring the trial protocols. Luteolin and apigenin are typically taken daily.

Are senolytics safe to combine with NMN?

Yes. They address different mechanisms, and combining senescent-cell clearance with NAD+ support is a common longevity strategy.

Browse the collection below, or see Polyphenols for the wider flavonoid range.