{"title":"Senolytics","description":"\u003cp\u003eSenescent cells are cells that have stopped dividing but refuse to die. In small numbers they serve useful purposes, helping wounds heal and suppressing tumors. As they accumulate with age, however, they secrete a cocktail of inflammatory signals, known as the senescence-associated secretory phenotype or SASP, that disrupts the healthy tissue around them. Researchers sometimes call them zombie cells. Senolytics are compounds studied for selectively clearing these cells, and the Welzo Ultra Purity Senolytics collection offers the two flavonoids with the strongest research at verified 98% purity.\u003c\/p\u003e\n\u003ch3\u003eSenolytics versus senomorphics\u003c\/h3\u003e\n\u003cp\u003eThe field uses two terms. \u003cstrong\u003eSenolytics\u003c\/strong\u003e are compounds studied for inducing senescent cells to self-destruct, which is why they are often taken intermittently rather than daily. \u003cstrong\u003eSenomorphics\u003c\/strong\u003e are compounds studied for suppressing the harmful SASP signals without necessarily clearing the cells. Fisetin is the most researched natural senolytic; luteolin is studied in both categories; and apigenin is primarily studied as a senomorphic. Together they cover both strategies. This is one of the newest areas in longevity science, and it sits alongside autophagy and NAD+ as the main mechanisms addressed in \u003ca href=\"\/collections\/longevity-healthy-aging\"\u003eLongevity \u0026amp; Healthy Aging\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eSenolytic ingredients in this collection\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFisetin Pro 500mg (98% purity)\u003c\/strong\u003e: a flavonoid found in strawberries and apples, identified in screening studies as one of the most potent natural senolytics. Human trials have typically used high doses for two consecutive days each month, which a 500mg capsule makes practical.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuronot Luteolin 500mg (98% purity)\u003c\/strong\u003e: a flavonoid found in celery, parsley and chamomile, studied as a senolytic and for its interaction with microglia, the brain's immune cells. It also appears in \u003ca href=\"\/collections\/brain-health-focus\"\u003eBrain Health \u0026amp; Cognitive Support\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApigenin\u003c\/strong\u003e: the chamomile flavonoid studied as a senomorphic that suppresses SASP signaling, and separately valued for sleep. See \u003ca href=\"\/collections\/sleep-recovery\"\u003eSleep \u0026amp; Recovery\u003c\/a\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWhy purity matters here\u003c\/h3\u003e\n\u003cp\u003eFlavonoids are poorly absorbed and quickly metabolized, so the dose that reaches tissue depends heavily on the purity of what you swallow. A 500mg capsule of 98% fisetin delivers 490mg of the active compound; a 500mg capsule of a 10% extract delivers 50mg. Welzo states purity on the label for exactly this reason. Taking fisetin with a meal containing fat can improve absorption, and some customers pair it with piperine or quercetin-containing foods.\u003c\/p\u003e\n\u003ch3\u003eHow senolytics fit into a longevity routine\u003c\/h3\u003e\n\u003cp\u003eMost customers run senolytics as a periodic layer on top of a daily foundation of NAD+ support and mitochondrial nutrients. A common pattern is daily NMN, resveratrol and TMG from \u003ca href=\"\/collections\/nad-boosters\"\u003eNAD+ Boosters\u003c\/a\u003e, with fisetin taken in a concentrated pulse once a month. Luteolin and apigenin are generally taken daily. Spermidine and urolithin A, which address cellular recycling rather than senescent-cell clearance, are the complementary mechanisms covered in \u003ca href=\"\/collections\/autophagy-support\"\u003eAutophagy Support\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eWhy Welzo Ultra Purity\u003c\/h3\u003e\n\u003cp\u003eWelzo is a UK-founded health company trusted by more than 200,000 customers and backed by over 27,000 five-star reviews across the Welzo platform. Every senolytic in this collection is manufactured to GMP standards, independently third-party tested for purity and potency, and supplied in vegan capsules with no fillers, binders or artificial colors. Batch certificates of analysis are available so the 98% on the label can be verified.\u003c\/p\u003e\n\u003ch3\u003eFrequently asked questions\u003c\/h3\u003e\n\u003ch4\u003eWhat is the best senolytic supplement?\u003c\/h4\u003e\n\u003cp\u003eFisetin has the most research as a natural senolytic and is the compound used in the leading human trials. Luteolin is the most studied alternative, and the two are often taken together.\u003c\/p\u003e\n\u003ch4\u003eShould senolytics be taken every day?\u003c\/h4\u003e\n\u003cp\u003eFisetin is usually taken intermittently, for example two consecutive days per month, mirroring the trial protocols. Luteolin and apigenin are typically taken daily.\u003c\/p\u003e\n\u003ch4\u003eAre senolytics safe to combine with NMN?\u003c\/h4\u003e\n\u003cp\u003eYes. They address different mechanisms, and combining senescent-cell clearance with NAD+ support is a common longevity strategy.\u003c\/p\u003e\n\u003cp\u003eBrowse the collection below, or see \u003ca href=\"\/collections\/polyphenol-supplements\"\u003ePolyphenols\u003c\/a\u003e for the wider flavonoid range.\u003c\/p\u003e","products":[{"product_id":"welzo-ultra-purity-luteolin-500","title":"Welzo Ultra Purity Luteolin 500mg","description":"\u003cp\u003eLuteolin hides in parsley, thyme, and chamomile, herbs you garnish with rather than eat by the handful. To get an amount worth talking about, you concentrate it, which is exactly what this 500mg serving does.\u003c\/p\u003e\u003cp\u003eIt's a flavonoid valued for broad antioxidant activity and immune support, equally at home in a longevity routine or an everyday wellness one. Think of it as a quiet all-rounder rather than a one-trick ingredient.\u003c\/p\u003e\u003cp\u003eThird-party tested and GMP-manufactured, with nothing you don't need.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e 2 capsules daily with food and water.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003e\u003cem\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/small\u003e\u003c\/p\u003e","brand":"Welzo Ultra Purity","offers":[{"title":"60 Capsules","offer_id":67677921247482,"sku":"5065026506559","price":33.99,"currency_code":"USD","in_stock":true},{"title":"120 Capsules","offer_id":67709124083962,"sku":"5065026506560","price":60.99,"currency_code":"USD","in_stock":true},{"title":"180 Capsules","offer_id":67709124116730,"sku":"5065026506561","price":86.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0836\/5336\/1914\/files\/luteilin_main_low.jpg?v=1791533725"},{"product_id":"welzo-ultra-purity-fisetin-500","title":"Welzo Ultra Purity Fisetin 500mg","description":"\u003cp\u003eFisetin is the compound that's made strawberries famous in longevity circles, except you'd need to eat roughly 37 pounds of them to match a single serving here. We skip the sugar and deliver a concentrated 500mg instead.\u003c\/p\u003e\u003cp\u003eIt's a flavonoid, and one of the most researched in the senescence conversation, which is why it's earned a spot in serious longevity routines for antioxidant support and healthy aging at the cellular level.\u003c\/p\u003e\u003cp\u003eBecause fisetin is fat-soluble, how you take it changes how much you absorb. Third-party tested and GMP-made.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Take with a meal that has some fat in it.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003e\u003cem\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/small\u003e\u003c\/p\u003e","brand":"Welzo Ultra Purity","offers":[{"title":"60 Capsules","offer_id":67677994254586,"sku":"5065026506542","price":36.99,"currency_code":"USD","in_stock":true},{"title":"120 Capsules","offer_id":67709123559674,"sku":"5065026506543","price":66.99,"currency_code":"USD","in_stock":true},{"title":"180 Capsules","offer_id":67709123592442,"sku":"5065026506544","price":93.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0836\/5336\/1914\/files\/fisetin_main_low.jpg?v=1791534103"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0836\/5336\/1914\/collections\/testimonial_fisetin.jpg?v=1791545199","url":"https:\/\/welzo.us\/collections\/senolytics.oembed","provider":"USA","version":"1.0","type":"link"}