{"title":"Polyphenols","description":"\u003cp\u003ePolyphenols are the compounds that give plants their color, their bitterness and much of their resilience against sun and stress. More than eight thousand have been identified, and a handful have become central to longevity research because they do something unusual: beyond acting as antioxidants, they interact with the signaling pathways that govern how cells age. The Welzo Ultra Purity Polyphenols collection offers the most studied of these compounds at verified purity, so the dose on the label is the dose that reaches you.\u003c\/p\u003e\n\u003ch3\u003eWhat makes polyphenols different from ordinary antioxidants\u003c\/h3\u003e\n\u003cp\u003eA standard antioxidant neutralizes free radicals and is spent. Polyphenols do that too, but their main interest to researchers lies elsewhere. Resveratrol is studied for activating sirtuins, the NAD+-dependent enzymes involved in cellular maintenance. Fisetin is studied as a senolytic. Luteolin interacts with microglia and neuroinflammation pathways. Apigenin binds GABA receptors and is studied as a senomorphic. In other words, polyphenols are signaling molecules as much as protective ones, which is why they sit at the intersection of \u003ca href=\"\/collections\/antioxidant-supplements\"\u003eAntioxidants\u003c\/a\u003e and \u003ca href=\"\/collections\/longevity-healthy-aging\"\u003eLongevity \u0026amp; Healthy Aging\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003ePolyphenols in this collection\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTrans-Resveratrol (98% purity)\u003c\/strong\u003e: the stilbene from grape skins and Japanese knotweed, and the polyphenol most frequently paired with NMN. The trans isomer is the biologically active form.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFisetin Pro 500mg (98% purity)\u003c\/strong\u003e: a flavonol found in strawberries, identified in screening studies as one of the most potent natural senolytics. See \u003ca href=\"\/collections\/senolytics\"\u003eSenolytics\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuronot Luteolin 500mg (98% purity)\u003c\/strong\u003e: a flavone found in celery and parsley, studied for brain health and cellular maintenance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApigenin\u003c\/strong\u003e: the chamomile flavone, formulated for sleep and studied for suppressing senescence-associated signaling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNMN \u0026amp; Resveratrol Stack\u003c\/strong\u003e: the classic longevity pairing of an NAD+ precursor with the polyphenol studied for sirtuin activation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eAbsorption: the polyphenol problem\u003c\/h3\u003e\n\u003cp\u003ePolyphenols are notoriously poorly absorbed and rapidly metabolized. Three things improve the odds. \u003cstrong\u003ePurity\u003c\/strong\u003e: a 98% extract delivers roughly ten times the active compound of a 10% extract in the same capsule. \u003cstrong\u003eFat\u003c\/strong\u003e: most flavonoids are better absorbed with a meal containing fat. \u003cstrong\u003ePiperine\u003c\/strong\u003e: black pepper extract is studied for slowing the metabolism of resveratrol in particular, which is why Welzo's Longevity Elite formula includes it. Welzo states purity on every label so you can compare on the number that matters.\u003c\/p\u003e\n\u003ch3\u003eHow to choose\u003c\/h3\u003e\n\u003cp\u003eTrans-resveratrol is the natural starting point and the polyphenol with the deepest research record; most customers take it daily alongside NMN from \u003ca href=\"\/collections\/nad-boosters\"\u003eNAD+ Boosters\u003c\/a\u003e. Fisetin is usually taken intermittently as a senolytic pulse. Luteolin suits customers focused on brain health, and apigenin suits those who want a polyphenol that also supports sleep. All four can be combined.\u003c\/p\u003e\n\u003ch3\u003eWhy Welzo Ultra Purity\u003c\/h3\u003e\n\u003cp\u003eWelzo is a UK-founded health company trusted by more than 200,000 customers and backed by over 27,000 five-star reviews across the Welzo platform. Every polyphenol here is manufactured to GMP standards, independently third-party tested for purity and potency, and supplied in vegan capsules with no fillers, binders or artificial colors. Batch certificates of analysis are available to verify the stated purity.\u003c\/p\u003e\n\u003ch3\u003eFrequently asked questions\u003c\/h3\u003e\n\u003ch4\u003eWhat is the difference between resveratrol and trans-resveratrol?\u003c\/h4\u003e\n\u003cp\u003eResveratrol exists in two forms. Trans-resveratrol is the stable, biologically active isomer used in research; cis-resveratrol is less active. Welzo supplies 98% trans-resveratrol.\u003c\/p\u003e\n\u003ch4\u003eAre polyphenols the same as flavonoids?\u003c\/h4\u003e\n\u003cp\u003eFlavonoids are the largest family within the polyphenol group. Fisetin, luteolin and apigenin are flavonoids; resveratrol belongs to a related family called stilbenes.\u003c\/p\u003e\n\u003ch4\u003eCan I get enough polyphenols from food?\u003c\/h4\u003e\n\u003cp\u003eA colorful diet supplies a broad range, but the doses used in longevity research, hundreds of milligrams of a single compound, are impractical from food alone, which is where standardized extracts come in.\u003c\/p\u003e\n\u003cp\u003eBrowse the collection below, or see \u003ca href=\"\/collections\/herbal-supplements\"\u003eHerbal \u0026amp; Botanical Supplements\u003c\/a\u003e for the wider plant-based range.\u003c\/p\u003e","products":[{"product_id":"welzo-ultra-purity-luteolin-500","title":"Welzo Ultra Purity Luteolin 500mg","description":"\u003cp\u003eLuteolin hides in parsley, thyme, and chamomile, herbs you garnish with rather than eat by the handful. To get an amount worth talking about, you concentrate it, which is exactly what this 500mg serving does.\u003c\/p\u003e\u003cp\u003eIt's a flavonoid valued for broad antioxidant activity and immune support, equally at home in a longevity routine or an everyday wellness one. Think of it as a quiet all-rounder rather than a one-trick ingredient.\u003c\/p\u003e\u003cp\u003eThird-party tested and GMP-manufactured, with nothing you don't need.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e 2 capsules daily with food and water.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003e\u003cem\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/small\u003e\u003c\/p\u003e","brand":"Welzo Ultra Purity","offers":[{"title":"60 Capsules","offer_id":67677921247482,"sku":"5065026506559","price":33.99,"currency_code":"USD","in_stock":true},{"title":"120 Capsules","offer_id":67709124083962,"sku":"5065026506560","price":60.99,"currency_code":"USD","in_stock":true},{"title":"180 Capsules","offer_id":67709124116730,"sku":"5065026506561","price":86.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0836\/5336\/1914\/files\/luteilin_main_low.jpg?v=1791533725"},{"product_id":"welzo-ultra-purity-fisetin-500","title":"Welzo Ultra Purity Fisetin 500mg","description":"\u003cp\u003eFisetin is the compound that's made strawberries famous in longevity circles, except you'd need to eat roughly 37 pounds of them to match a single serving here. We skip the sugar and deliver a concentrated 500mg instead.\u003c\/p\u003e\u003cp\u003eIt's a flavonoid, and one of the most researched in the senescence conversation, which is why it's earned a spot in serious longevity routines for antioxidant support and healthy aging at the cellular level.\u003c\/p\u003e\u003cp\u003eBecause fisetin is fat-soluble, how you take it changes how much you absorb. Third-party tested and GMP-made.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Take with a meal that has some fat in it.\u003c\/p\u003e\u003cp\u003e\u003csmall\u003e\u003cem\u003e† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/small\u003e\u003c\/p\u003e","brand":"Welzo Ultra Purity","offers":[{"title":"60 Capsules","offer_id":67677994254586,"sku":"5065026506542","price":36.99,"currency_code":"USD","in_stock":true},{"title":"120 Capsules","offer_id":67709123559674,"sku":"5065026506543","price":66.99,"currency_code":"USD","in_stock":true},{"title":"180 Capsules","offer_id":67709123592442,"sku":"5065026506544","price":93.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0836\/5336\/1914\/files\/fisetin_main_low.jpg?v=1791534103"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0836\/5336\/1914\/collections\/Fisetin_Lifestyle.jpg?v=1791545075","url":"https:\/\/welzo.us\/collections\/polyphenol-supplements.oembed","provider":"USA","version":"1.0","type":"link"}